Hi Zach,
I have not used Pro Marine resin, so these comments are based upon my results using other epoxies.
Yes, you can sand epoxies. Start with a coarse wet/dry sandpaper. In general, epoxies don’t do well with the heat produced from the friction of a belt sander. If you want to try, the resin surface needs to stay wet. Please take proper safety precautions as I want to be sure you don’t hurt yourself.
If you end with a 1000 grit or higher sandpaper, you should not see any sanding lines when you pour the next layer. I think ending with 3000 grit is a good idea.